Abcore is an established CRO, with a platform for antibody discovery and single domain VHH antibody discovery. We work with some of the largest biotechnology and pharmaceutical companies in the world. We have a full platform of services based around single domain antibody discovery and VHH characterization.
- Single Domain Antibody Discovery
- Single Domain Antibody Phage Display
- Phage Library Panning
- Phage Library Screening
- Single Domain Antibody Expression and Purification
- Single Domain Antibody Humanization
- Single Domain Antibody Cell Binding
- Generation of Naïve Phage Libraries
- Generation of Immunized Phage Libraries
Abcore has an entire platform built around discovery and characterization of VHH single domain antibodies. We have a farm with over 300 llamas and 150 alpacas and have highly characterized naïve phage libraries. We have optimized processes for generation of these libraries using proprietary primers that have higher coverage than the traditional published primers. We have a proprietary process to screen all our single domain antibodies off-phage, so we have no non-specific phage binding and have no attrition rate in our list of positive, unique single domain antibody binders due to sticky phage.
Once positive VHH sequences are discovered, Abcore can purify the single domain antibody, characterize the VHH antibodies, and optimize the single domain antibodies for various experimental and clinical applications.