Abcore is an established CRO, with a platform for antibody discovery and nanobody discovery. We work with some of the largest biotechnology and pharmaceutical companies in the world. We have a full platform of services based around single domain antibody discovery and nanobody characterization.
- Nanobody Discovery
- Nanobody Phage Display
- Phage Library Panning
- Phage Library Screening
- Nanobody Expression and Purification
- Nanobody Humanization
- Nanobody Cell Binding
- Generation of Naïve Phage Libraries
- Generation of Immunized Phage Libraries
Abcore has an entire platform built around discovery and characterization of VHH nanobodies. We have a farm with over 300 llamas and 150 alpacas and have highly characterized naïve phage libraries. We have optimized processes for generation of these libraries using proprietary primers that have higher coverage than the traditional published primers. We have a proprietary process to screen all our single domain antibodies off-phage, so we have no non-specific phage binding and have no attrition rate in our list of positive, unique nanobody binders due to sticky phage.
Once positive VHH sequences are discovered, Abcore can purify the nanobodies, characterize the nanobodies, and optimize the nanobodies for various experimental and clinical applications.