APC Antibodies

Allophycocyanin, also known as APC, is a bright fluorescent probe. APC antibodies are conjugated, or attached, to allophycocyanin. APC is a rather large protein containing multiple fluors. Its approximate molecular weight is 80 kd. APC is an accessory pigment to chlorophyll and is found in blue-green algae. Allophycocyanin is water soluble. ACP absorbs and emits light that is the color red. It emits at 680 nm. Direct APC conjugates are relatively easy to make. The protocol involves preparation of APC, derivitization of APC, reduction of the immunoglobulin, and then the covalent conjugation. Abcore Inc. offers antibodies prepared and conjugated to APC.

CD3 antibody (APC) has been used in research regarding B cell lymphoma as well as brain tumors. The CD3 complex is a mediator of signal transduction localized on the cell membrane. Defects in CD3 and anti- CD3 antibody (APC) can cause several severe immunodeficiency disorders among a specific group of ailments characterized by low antibody levels and specific immunities due to poor T- cell development. Anti-Cytokeratin antibody (APC) binds to the target cytokeratin. Cytokeratin regulates the activity of kinases PKC and SRC. Cytokeratin is expressed in the plasma membrane of cells. Defects in KRT1 are the cause of bullous congenital ichthyosiform erythroderma and palmoplantar keratoderma non-epidermolytic. Bullous congenital ichthyosiform erythroderma affected individuals often present with a blistering rash followed by the degeneration of the lower spinous layer of the epidermis or skin. Palmoplantar keratoderma non-epidermolytic is an inherited autosomal dominant condition characterized by waxy keratoderma (horns on skin) involving the palms and soles of the feet.